LEE, YEON SUN, Ph.D. Department of Pharmacology, College of Medicine, University of Arizona 1501 N. Campbell Ave, Tucson, AZ 85724, USA Tel: 520-626-2680 / E-Mail: yeon@email.arizona.edu. AREAS OF INTEREST ¨ Peptide and Peptidomimetic Drug Design ¨ Peptide Structure-Function ¨ Topographical Considerations in Molecular Recognition ¨ Organic, Amino Acid and Peptide Synthesis ¨ Pain mechanisms and Drug Abuse  EDUCATION 1994 – 1995: Post-Doc, Organic Chemistry Lab, Korea Institute of Science and Technology (KIST), Seoul, Korea 1989 – 1994: Ph.D., Dept. of Chemistry, The Graduate School of Ewha Womans University, Seoul, Korea 1984 – 1986: M.S., Dept. of Chemistry, The Graduate School of Ewha Womans University, Seoul, Korea 1978 – 1982: B.S., Dept. of Chemistry, Ewha Womans University, Seoul, Korea EXPERIENCE Research in Academia 07/2017 – present: Research Associate Professor, Dept. of Pharmacology, University of Arizona, Tucson, Az 03/2013 – 06/2017: Research Assistant Professor, Dept. of Chemistry and Biochemistry, University of Arizona, Tucson, Az 01/2010 – 03/2013: Research Scientist, Dept. of Chemistry and Biochemistry, University of Arizona, Tucson, Az 09/2008 – 12/2009: Associate Research Scientist, Dept. of Material Science & Engineering, University of Arizona, Tucson, Az 01/2008 – 09/2008: Associate Research Scientist, Dept. of Pharmacology & Toxicology, University of Arizona, Tucson, AZ 2000 – 2007: Research Associate, Dept. of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 1986 – 1987: Researcher, Dept. of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejon, Korea Industry 2016 – present:Senior Director (part time), Peptide Logic, Ltd. San Diego, CA 1995 – 2000: Principal Researcher, Organic Synthesis Lab., Research Institute, Hyundai Pharm. Ind. Co., Ltd. Seoul, Korea Teaching Current advising; Patrick McCarty (Dept. of Chemistry and Biochemistry); Kevin Wong (Dept. of Chemistry and Biochemistry) 2009: Adjunct Professor for Fundamental Chemistry, 5 credits, 6 hours/week, Pima Community College, Tucson, AZ 1994: Part-time Lecturer for General Chemistry, Dept. of Chemistry, Ewha Womans University, Seoul, Korea 1991-1992:Part-time Lecturer for General Chemistry, Dept. of Chemistry, Hankook University of Foreign Studies, Seoul, Korea 1989 & 1982-1984:Teaching Assistance, Dept. of Chemistry, Hankook University of Foreign Studies, Seoul, Korea HONORS, AWARDS, AND EXTRACURRICULAR ACTIVITIES ¨ Recipient of 2015 Copernicus Award, College of Science, University of Arizona; Hruby Allumni Award, 2001 ¨ Membership: American Peptide Society; Korean Chemical Society ¨ Editorial Board Member: International Archives of Clinical Pharmacology ¨ Judge for Young Investigator Competition at American Peptide Symposium ¨ Reviewer for the following Journals: ACS Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Chemical Neuroscience, Biochemistry, Bioorganic Medicinal Chemistry Letters, British Journal of Pharmacology, Chemical Biology and Drug Design, Nanomedicine-Nanotechnology Biology and Medicine, Journal of Peptide Science, Aminoacids,  Bulletin of the Korean Chemical Society ¨ Referee for grant proposal: Neurological Foundation of New Zealand, 2015 - ; Irish Research Center, 2018- SELECTED ACCOMPLISHMENTS ¨ Discovered a novel dynorphin A analogue for the treatment of chronic neuropathic pain. This discovery was subsequently patented, published in The Journal of the American Chemical Society, selected as a Key Drug Discovery Article in Global Medical Discovery (https://globalmedicaldiscovery.com), and introduced by Biological Research Information Center (BRIC) as a webinar (http://bric.postech.ac.kr/vod) and as a recommended research article (http://bric.postech.ac.kr/hanbitsa).  ¨ Discovered highly potent opioid ligands for the treatment of chronic pain. Selected as “This week in therapeutics” of SciBX (Science-Business eXchange) by Nature publishing group. ¨ Developed novel approach to pain treatment: multifunctional ligands in a single molecule.  ¨ Pilot Plant Construction for the production of NSC-amino acids. Supported by the Ministry of Science & Technology, Korea. ¨ Developed 6 new amino acid derivatives for peptide synthesis. ¨ Achieved KFDA (Korea Food & Drug Administration) approved “Preparation of calcitonin” which was publicized in three newspapers (The Pharmacy Newspaper, The Pharmacy World Newspaper, and Maeil Economy Newspaper) in February, 1998. INVITED PRESENTATIONS ¨ “Discovery of a ligand with a new biological profile, MOR/DOR agonist and KOR antagonist activity, for the treatment of pain” CPDA Conference 2018. August 2, 2018, Boston, USA. ¨ “Neuroexcitatory Effects of Dynorphin A” 2nd International Congress on Neuroimmunology & Therapeutics, December 2, 2016, Atlanta, USA. ¨ “Development of Novel Nanopeptides for the Treatment of Chronic Neuropathic Pain” Dec. 8, 2015, College of Science, University of Warsaw, Warsaw, Poland. ¨  “Discovery of Non-opioid Dynorphin A Analogues for the Treatment of Chronic Neuropathic Pain” June 12, 2014, Biological Research Information Center, Pohang University, Korea. (Web Seminar) ¨  “Discovery of Non-opioid Dynorphin A Analogues for the Treatment of Chronic Neuropathic Pain” May, 2014, at 6 Universities or Institutes including College of Pharmacy, Seoul National University, Seoul, Korea. ¨  “Multifuctional Peptide Ligands for the Treatment of Pain”, September, 2008, at 4 Universities or Institutes including Life Science Center, Korea Institute of Science and Technology (KIST), Seoul, Korea ¨  “Synthesis of Salmon Calcitonin”, November, 1999, Computer Aided Molecular Design Research Center, Soongsil University, Seoul, Korea. PATENTS       Yeon Sun Lee; Victor J. Hruby; Frank Porreca “Multifunctional Opioid Receptor Ligands and Methods of Treating Pain” US20180127465 (A120180510), 2018. Yeon Sun Lee; Victor J. Hruby; Frank Porreca “Multifunctional Opioid Receptor Ligands and Methods of Treating Pain” PCT Int. Appl. WO2016187537(A120161124), 2016 Yeon Sun Lee; Victor J. Hruby; Josephine Lai; Frank Porreca “Discovery of Novel Amphipathic Ligands for the Dynorphin Binding Site on the Bradykinin Receptor” PCT Int. Appl. WO2014190313(A2), 2014. Hack-Joo Kim; Yeon Sun Lee; Hyun Jin Lee “Amino acid Derivatives”, Patent Cooperation Treaty, PCT/KR 97/00174 (Publication NO. WO 99/14189), 1997. Hack-Joo Kim; Yeon Sun Lee; Hyun Jin Lee “Process for the Preparation of Calcitonin” Patent Cooperation Treaty, PCT/KR 97/00173 (Publication NO. WO 99/14238), 1997. Hokoon Park; Yong Sup Lee; Yeon Sun Lee “C-3 Substituted New Cephalosporins and process for the preparation of them”, Korean Patent, 10-1995-007659 (Publication NO 10-1996-037684, Registration NO 10-162866-0000), 1995. PUBLICATIONS Peer-Reviewed Articles Lindsey M. Snyder; Michael C. Chiang; Emanuel Loeza-Alcocer; Yu Omori; Junichi Hachisuka; Tayler D. Sheahan; Jenna R. Gale; Peter C. Adelman; Elizabeth I. Sypek; Stephanie A. Fulton; Robert L. Friedman; Margaret C. Wright; Melissa Giraldo Duque; Yeon Sun Lee; Zeyu Hu; Huizhen Huang; Xiaoyun Cai; Kimberly A. Meerschaert; Vidhya Nagarajan; Toshiro Hirai; Gregory Scherrer; Daniel H. Kaplan; Frank Porreca; Brian M. Davis; Michael S. Gold; Richard Koerber; Sarah E. Ross “Kappa Opioid Receptor Distribution and Function in Primary Afferents”Neuron, 2018, 99, 1274-1288. Michael Remesic; Giorgia Macedonio; Adriano Mollica; Frank Porreca; Victor J. Hruby; Yeon Sun Lee “Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors” Med. Chem. 2018, 26, 3664-3667. Michael Remesic; Victor J. Hruby; Frank Porreca; Yeon Sun Lee “Recent Advances in the Realm of Allosteric Modulators for the Opioid Receptors for Future Therapeutics” ACS Chem. Neurosci. 2017, 8, 1147-1158. Cyf N. Ramos-Colon; Yeon Sun Lee; Michael Remesic; Sara M. Hall; Justin LaVigne; Peg Davis; Alexander J. Sandweiss; Mary I. McIntosh; Jessica Hanson; Tally M. Largent-Milnes; Todd W. Vanderah; John Streicher;, Frank Porreca; and Victor J. Hruby. “Structure Activity Relationships of [des-Arg7]- Dynorphin A Analogues at the Kappa Opioid Receptor” J. Med. Chem. 2016, 59(22), 10291-10298. Yeon Sun Lee; Michael Remesic; Cyf Ramos-Colon; Sara M. Hall; Alexander Kuzmin; David Rankin; Frank Porreca; Josephine Lai; Victor J. Hruby “Cyclic non-opioid dynorphin A analogues for the bradykinin receptors” Bioorganic. Med. Chem. Lett. 2016, 26(22), 5513-5516. Sara M. Hall; Lindsay LeBaron; Cyf Ramos-Colon; Chaoling Qu, Jennifer Yanhua Xie; Frank Porreca; Josephine Lai; Yeon Sun Lee; Victor J. Hruby. “Discovery of stable non-opioid dynorphin A analogues interacting at the bradykinin receptors for the treatment of neuropathic pain” ACS Chem. Neurosci. 2016, 7, 1746-1752. Mohammad Rashedul Islam; Li Yang, Yeon Sun Lee; Victor J Hruby; Thomas J Abbruscato “Enkephalin-fentanyl multifunctional opioids as potential neuroprotectants for ischemic stroke treatment: Comparison to biphalin and fentanyl” Curr. Pharm. Des., 2016, 22(42), 6459-6468. Yeon Sun Lee; Robert Kupp; Michael V. Remesic; Cyf Ramos-Colon; Sara M. Hall; David Rankin; Frank Porreca; Josephine Lai; Victor J. Hruby “Various modifications of the amphipathic dynorphin A phamacophore for rat brain bradykinin receptors” Chem. Bio. & Drug Des., 2016, 88, 615-619. Scott M. Cowell; Yeon Sun Lee “Biphalin: the foundation of bivalent ligands” Curr. Med. Chem., 2016, 23(29), 3267-3284. Michael Remesic; Yeon Sun Lee; Victor J. Hruby “Cyclic opioid peptides” Curr. Med. Chem., 2016, 23(13), 1288-1303. (Selected by the Editor-in-Chief as Editor’s choice to promote through a press release at EurekAlert platform, http://www.eurekalert.org/pub_releases/2016-07/bsp-cop071316.php) Sara M. Hall; Yeon Sun Lee; Victor J. Hruby “Dynorphin A analogues for the treatment of chronic neuropathic pain” Fut. Med. Chem., 2016, 8, 165-177. Dina V. Hingoran; Luis A. Montano; Edward A. Randtke; Yeon Sun Lee; Julio Cardenas Rodriguez; Mark D. Pagel “A single diamagnetic cataly CEST MRI contrast agent that detects cathepsin B enzyme activity by using a ratio of two CEST signals” Contrast Media Molec Imaging, 2016, 11(2), 130-138. Yeon Sun Lee; Sara M. Hall; Cyf Ramos-Colon; Michael Remesic; David Rankin; Todd W. Vanderah; Frank Porreca; Josephine Lai; Victor J. Hruby “Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors” Receptors Clin Investig 2015, doi: 10.14800/rci.517. Mehr-un-Nisa; Munawar A. Munawar; Yeon Sun Lee; David Rankin; Jawaria Munir; Josephine Lai; Misbahul A. Khan; Victor J. Hruby “Design, synthesis, and biological evaluation of a series of bifunctional ligands of Opioids/SSRIs” Bioorganic. Med. Chem. 2015, 23, 1251-1259. Guillermo Martinez-Ariza; Jose Nunez-Rios; Yeon Sun Lee; Christopher Hulme “ Acetyl cyanide as a cyanide source in a tandem catalyst-free modified Groebke-Blackburn-Bienaym’s [4+1]-cycloaddition-Strecker cascade” Tetrahedron Lett., 2015, 56, 1038-1048. Yeon Sun Lee; Sara M. Hall; Cyf Ramos-Colon; Michael Remesic; Lindsay LeBaron, Ann Nguyen;David Rankin, Frank Porreca; Josephine Lai; Victor J. Hruby “Modification of Amphipathic Non-opioid Dynorphin A Analogues for Rat Brain Bradykinin Receptors” Bioorg. Med. Chem. Lett., 2015, 25, 30-33. Steve M. Fernandes; Yeon Sun Lee; Robert J. Gillies; Victor J. Hruby “Synthesis and evaluation of bivalent ligands for bidning to the human melanocortin-4 receptor” Bioorganic. Med. Chem., 2014, 22, 6360-6365. Yeon Sun Lee; David Rankin; Sara M. Hall; Cyf Ramos-Colon; Jose J. Ortiz; Robert Kupp; Frank Porreca; Josephine Lai; Victor J. Hruby “Structure-activity relationships of non-opioid [des-Arg7]-dynorphin A analogues for bradykinin receptors” Bioorg. Med. Chem. Letts., 2014, 24, 4976-4979. Kirsty Bannister; Yeon Sun Lee; Leonor Goncalves; Frank Porreca; Josephine Lai; Anthony H. Dickenson “Neuropathic plasticity in the opioid and non-opioid actions of dynorphin A fragments and their interactions with bradykinin B2 receptors on neuronal activity in the rat spinal cord” Neuropharmacology, 2014, 85, 375-383. Yeon Sun Lee; Dhanasekaran Muthu; Sara M. Hal;, Cyf Ramos-Colon; David Rankin;Jackie Hu; Alexander J. Sandweiss; Milena De Felice; Jennifer Yanhua Xie,; Todd W. Vanderah; Frank Porreca; Josephine Lai; Victor J. Hruby “Discovery of Amphipathic Dynorphin A Analogues to Inhibit the Neuroexcitatory Effects of Dynorphin A through Bradykinin Receptors in the Spinal Cord” J. Am. Chem. Soc., 2014, 136, 6608-6616. (Selected as a Key Drug Discovery Article in Global Medical Discovery) Alexander T. Podolsky; Alexander Sandweiss, Jackie Hu; Edward J. Bilsky; Jim P. Cain; Vlad K. Kumirov; Yeon Sun Lee; Victor J. Hruby; Ruben S. Vardanyan; Todd W. Vanderah “Novel fentanyl-based dual µ/δ–opioid agonists for the treatment of acute and chronic pain” Life Sci., 2013, 93, 1010-1016. Yeon Sun Lee;  Hongchang Qu; Peg Davis;  Shou-wu Ma;  Josephine Lai;  Frank Porreca; Victor J. Hruby “Chiral effect of a phenylalanin in position 3 of the Dmt1-L(or D)-Tic2 pharmacophore on the opioid functional activities” ACS Med. Chem. Lett., 2013, 4, 656-659. Ravil R. Petrov; Yeon Sun Lee; Ruben S. Vardanyan; Lu Liu; Shou-wu Ma; Peg Davis; Josephine Lai; Frank Porreca; Todd W. Vanderah; Victor J. Hruby “Effect of anchoring 4-anilidopiperidines to opioid peptides” Bioorg. Med. Chem. Lett., 2013, 23, 3434-3437. Katherine E. Hanlon; Dave S. Herman; Richard S. Agnes; Tally M. Largent-Milnes; Isuru R. Kumarasinghe; Shou-wu Ma; Wenhong Guo; Yeon Sun Lee; Michael H. Ossipov; Victor J. Hruby; Josephine Lai; Frank Porreca; Todd W. Vanderah “Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain’ Brain Res., 2011, 1395, 1-11. Yeon Sun Lee;Vinod Kulkarani; Scott M. Cowell; Shou-wu Ma;Peg Davis;Katherine E. Hanlon; Todd W. Vanderah; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J. Hruby“Development of poten µ and δ opioid agonists with high lipophilicity” J. Med. Chem., 2011, 54(1), 382-386. (Selected as “This week in therapeutics” of SciBX (Science-Business eXchange) by Nature publishing group.) Yeon Sun Lee;Steve Fernandes;Vinod Kulkarani; Alexander Mayorov; Peg Davis;Shou-wu Ma;Kathy Brown; Robert J. Gillies; Josephine Lai; Frank Porreca; Victor J. Hruby“Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain” Bioorg. Med. Chem. Lett., 2010, 20, 4080-4084. Christopher Hulme; Shashi Chappeta; Chris Griffith; Yeon Sun Lee; Justin Dietrich "An efficient solution phase synthesis of triazadibenzoazulenones: 'designer isonitrile free' methodology enabled by microwaves" Tetrahedron Lett., 2009, 50, 1939-1942. Christopher Hulme; Yeon Sun Lee “Emerging approaches for the syntheses of bicyclic imidazo[1,2-x]-heterocycles” Molecular Diversiy, 2008, 12(1), 1-15. Richard S. Agnes; Jinfa Ying; Katalin E. Kövér; Yeon Sun Lee;  Peg Davis; Shou-wu Ma; Hamid Badghisi; Frank Porreca; Josephine Lai; Victor J. Hruby “Structure-Activity Relationships of Bifunctional Cyclic Disulfide Peptides Based on Overlapping Pharmacophores at Opioid and Cholecystokinin Receptors” Peptides, 2008, 29(8), 1413-1423. Byoung J. Min; Xuyuan Gu; Takashi Yamamoto; Ravil R. Petrov; Hongchang Qu; Yeon Sun Lee; Victor J. Hruby “Synthesis of a novel benzyl-octahydropyrazino[1,2-a]pyrimidin-6-one derivative as a convenient internal bicyclic peptidomimetic” Tetrahedron Lett., 2008, 49(14), 2316-2319. Yeon Sun Lee; Richard S. Agnes; James P. Cain; Vinod Kulkrani; Minying Cai; Christine Salibay; Kathy Ciano; Ravil Petrov; Alexander Mayorov; Josef Vagner; Dev Trivedi; Peg Davis;Shou-wu Ma;Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J. Hruby “Opioid and Melanocortin Receptors: Do they have Overlapping Pharmacophores?” Biopolymers: Peptide Science, Dedication issue to Bruce Merrifield, 2007, 90(3), 433-438. Yeon Sun Lee; Ravil Petrov; Chad K. Park; Shou-wu Ma; Peg Davis; Josephine Lai; Frank Porreca; Ruben Vardanyan;Victor J. Hruby “Development of novel enkephalin analogues which have enhanced opioid activities at both m and d opioid receptors” J. Med. Chem., 2007, 50(22), 5528-5532. Yeon Sun Lee;Joel Nyberg;Sharif Moye; Richard S. Agnes; Peg Davis;Shou-wu Ma;Josephine Lai; Frank Porreca; Victor J. Hruby“Understanding the structural requirements of 4-anilidopiperidine analogues for the biological activities at m and d opioid receptors” Bioorg. Med. Chem. Lett., 2007, 17, 2161-2165. Yeon Sun Lee;Richard S. Agnes; Peg Davis;Shou-wu Ma;Hamid Badghisi; Josephine Lai; Frank Porreca; Victor J. Hruby“Partial Retro-inverso, Retro, and Inverso Modifications of Hydrazide Linked Bifunctional Peptides for Opioid and CCK Receptors” J. Med. Chem., 2007, 50(1), 165-168. James P. Cain; Alexander V. Mayorov; Minying Cai; Hui Wang; Bahar Tan; Kevin Chandler; YeonSun Lee; Ravil R. Petrov; Dev Trivedi; Victor J. Hruby, “Design, Synthesis, and Biological Evaluation of a New Class of Small Molecule Peptide Mimetics Targeting the Melanocortin Receptors” Bioorg. Med. Chem. Lett., 2006, 5462-5467. Ravil R. Petrov; Ruben S. Vardanyan; Yeon Sun Lee; Shou-wu Ma; Peg Davis; Lucinda J. Begay; Josephine Y. Lai; Frank Porreca; and Victor J. Hruby, “Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity” Bioorg. Med. Chem. Lett., 2006, 4946-4950. Victor J. Hruby; Frank Porreca; Henry .I. Yamamura; Gordon Tollin; Richard Agnes; Yeon Sun Lee; Minying Cai; Isabel Alves; Scott M. Cowell; Peg Davis; Eva Varga; Peg Davis; Zdzislaw Salamon; William Roeske; Todd W. Vanderah; Josephine Lai “New Paradigms and Tools in Drug Design for Pain and Addiction” J. Am. Assoc. Pharm. Sci., 2006, 8(3), E450-E460. Richard S. Agnes; Yeon Sun Lee; Peg Davis; Shou-Wu Ma; Hamid Badghisi; Josephine Lai; Frank Porreca; Victor J. Hruby “Structure Activity Relationships of Bifunctional Peptides Based on Overlapping Pharmacophores at Opioid and Cholecystokinin Receptors” J. Med. Chem., 2006, 49, 2868-2875. Yeon Sun Lee; Richard S. Agnes; Peg Davis; Shou-Wu Ma; Josephine Lai; Frank Porreca; Victor J. Hruby “Design and Synthesis of Novel Hydrazide Linked Bifunctional Peptides as µ/δ Opioid Receptor Agonists and CCK-1/CCK-2 Receptor Antagonists” J. Med. Chem., 2006, 49(5), 1773-1780. Scott M. Cowell; Yeon Sun Lee; Victor J. Hruby “Exploring Ramachandran and Chi Space: Conformationally Constrained Amino Acids and Peptides in the Design of Bioactive Polypeptide Ligands.” Curr. Med. Chem., 2004, 11(21), 2785-2798. Isabel Alves; Scott Cowell; Yeon Sun Lee; Xuejun Tang; Peg Davis; Frank Porreca; and Victor J. Hruby “ A Novel 3-step Enatioselective Synthesis of Pyrenylalanine with Subsequent Incorporation into Opioid, CCK, and Melanotropin Ligands” Biochem. Biophys. Res. Commun., 2004, 318(2), 335-340. Victor J. Hruby; Richard S. Agnes; Peg Davis; Show-Wu Ma; Yeon Sun Lee; Todd W. Vanderah; Josephine Lai; Frank Porreca “Design of novel peptide ligands which have opoid agonist activity and CCK antagonist activity for the treatment of pain”, Life Sci., 2003, 73(6), 699-704. Yeon Sun Lee; Hyun Jin Lee; Pavel I. Pozdnyakov; Vladimir V. Samukov; Hack-Joo Kim “A Convergent Liquid Phase Synthesis of Salmon Calcitonin”, J. Pep. Res., 1999, 54, 328-335. Jin-Il Park; Seung-Han Lee; Yeon Sun Lee; Hack-Joo Kim “Facile Synthesis of 2-(4-Nitrophenylsulfonyl)ethoxycarbonyl-O-t-butyl-L-serine, Threonine, and Tyrosine”, Bull. Kor. Chem. Soc., 1999, 20(2), 244-246. Yeon Sun Lee; Hyun Jin Lee; Pavel L. Pozdnyakov; Vladimir V. Samukov; Hack-Joo Kim "New Amino acid Derivatives for the Synthesis of Pharamaceutical Peptides by Liquid Phase Method: Boc-Asp(OPse)-OH DCHA and Boc-Glu(OPse)-OH DCHA", Bull. Kor. Chem. Soc., 1998, 19(7), 717-719. Yeon Sun Lee; Hyun Jin Lee; Pavel I. Pozdnyakov; Vladimir V. Samukov; Hack-Joo Kim “Application of the 2-(phenylsulfonyl)ethoxycarbonyl Group for the ε-Amino Function of Lysine in Liquid Phase Peptide Synthesis”, Bull. Kor. Chem. Soc., 1998, 19(6) 696-698. Yong Sup Lee; Yeon Sun Lee; Hokoon Park “Synthesis and Biological Activities of C-3 Directly Heterocycle Carbon Substituted New Cephalosporins”, J. Antibiot., 1996, 49(4), 405-407. Sun Ho Jung; Yeon Sun Lee; Hokoon  Park; Dong-Sook  Kwon “Transannular Diels-Alder Reaction of a Macrocyclic Triene, (E,E,E)-13-Trideca-2,8,10-trienolactone”, Tetrahedron Lett., 1995, 36(7), 1051-1054. Sun Ho Jung; Yeon Sun Lee; Hokoon Park; Dong-Sook Kwon “Dimerization in the Intramolecular Horner-Emmons Reactions: Synthesis of Macrocyclic Diels-Alder Substrates, Hexaenodilactones”, Bull. Kor. Chem. Soc., 1994, 15(12), 1132-1133. Proceedings and Reports Yeon Sun Lee; Sara M. Hall; Cyf Ramos-Colon; Michael Remesic; Alexander Kuzmin; David Rankin; Todd W. Vanderah; Frank Porreca; Josephine Lai; Victor J. Hruby “Amphipathic Non-opioid Dynorphin A Analogs to Inhibit Neuroexcitatory Effects at Central Bradykinin Receptors” Proceeding of the 24th  American Peptide Symposium, 2015, doi: 10.17952/24APS.2015. Sara M. Hall; Yeon Sun Lee; Cyf Ramos-Colon; Frank Porreca; Josephine Lai; Victor J. Hruby “Structure Activity Relationship of Stable Dynorphin A-(2-13) Analogues Interacting at the Bradykinin-2 Receptor” Proceeding of the 24th  American Peptide Symposium, 2015, doi: 10.17952/24APS.2015. Cyf Ramos-Colon; Yeon Sun Lee; Sara M. Hall; Josephine Lai; Frank Porreca; Victor J. Hruby “Structure-Activity Relationship Studies of Dynorphin A Analogs at the Kappa Opioid Receptor” Proceeding of the 24th  American Peptide Symposium, 2015, doi: 10.17952/24APS.2015. Yeon Sun Lee;Sara M. Hall; Cyf Ramos-Colon; Dhana Muthu; David Rankin; Frank Porreca; Josephine Lai;  Victor J. Hruby“[Des-Arg7]-Dynorphin A Analogues for Bradykinin-2 Receptor” Proceeding of the 23rd  American Peptide Symposium, 2013, 134. Sara M. Hall; Yeon Sun Lee;Cyf Ramos-Colon; David Rankin; Frank Porreca; Josephine Lai;  Victor J. Hruby “Structure Activity Relationship of Dynorphin A(2-13) Analogs at the Bradykinin-2 Receptor” Proceeding of the 23rd  American Peptide Symposium, 2013, 128. Cyf Ramos-Colon; Yeon Sun Lee;Sara M. Hall; David Rankin; Frank Porreca; Josephine Lai;  Victor J. Hruby“Development of  Potent Dynorphin A Analogues as Kappa Opioid Receptor Antagonists” Proceeding of the 23rd  American Peptide Symposium, 2013, 142. Sara M. Hall; David Rankin; Alice Cai; Victor J. Hruby; Yeon Sun Lee; Josephine Lai “High Affinity Binding of Dynorphin A-(2-13) at the Bradykinin-2 Receptor” The FASEB Journal, 2012, 26, 836. Yeon Sun Lee;David Rankin; Briana Paisely; Sara M. Hall; Dhana Muthu; Jose J. Ortiz; Frank Porreca; Josephine Lai;  Victor J. Hruby“Development of non-opioid dynorphin A analogs for the modulation of pain” Proceeding of the 22nd American Peptide Symposium, 2011, 348. Ruben Vardanyan; Yeon Sun Lee;James P. Cain; Peg Davis; Todd W. Vanderah; Josephine Lai; Frank Porreca; Victor J. Hruby“Synthesis and investigations of peptidic-non-peptidic bivalent ligands for treatment of pain” Proceeding of the 22nd American Peptide Symposium, 2011, 358. Josaphine Lai; David Rankin; Alice Cai; Yeon Sun Lee; Victor J. Hruby; Frank Porreca “Dynorphin A is a Competitive, Partial Agonist at the Bradykinin Receptors” The FASEB Journal, 2011, 25, 626. Yeon Sun Lee; Ravil Petrov; Vinod Kulkarni; Shou-wu Ma; Peg Davis; Janice Oyarzo; Todd Vanderah; Josephine Lai; Frank Porreca; Ruben Vardanyan; Victor J. Hruby “Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety" Advances in Experimental Medicine and Biology, 2009, 611, 517. Vinod Kulkarni; Yeon Sun Lee; Christine Salibay; Peg Davis; Shou-wu Ma; Frank Porreca; Victor J. Hruby “Novel analogues of Bifunctional Ligands for Opioid and Melanocortin-4 Receptors” ” Advances in Experimental Medicine and Biology, 2009, 611, 195. Yeon Sun Lee; Vinod Kulkarni; Shou-wu Ma; Hamid Badghis; Peg Davis; Tally Largent; Todd Vanderah, Josephine Lai; Frank Porreca; Victor J. Hruby “Chimeric multifunctional ligands for the treatment of pain” Peptides 2006, Proceeding of the 29th European Peptide Symposium, 2006, 172. James P. Cain; Byoung J. Min; Alexander V. Mayorov; Minying Cai; Hui Wang; Sun Wallace; Bahar Tan; Kevin Chandler; YeonSun Lee; Ravil R. Petrov; Dev Trivedi; Victor J. Hruby “Novel bicyclic templates for peptidomimetics targeting GPCRs” Peptides 2006, Proceeding of the 29th European Peptide Symposium, 2006, 716. Ravil R. Petrov; Ruben S. Vardanyan; Yeon Sun Lee; Shou-wu Ma; Peg Davis; Josephine Lai; Frank Porreca; Victor J. Hruby “Fentephalines: Dimeric bioactive peptide s based on amino acids coupled to 4-anilino-N-phenethyl-piperidine” Chimeric multifunctional ligands for the treatment of pain” Peptides 2006, Proceeding of the 29th European Peptide Symposium, 2006, 304. Yeon Sun Lee; Joel Nyberg; Sharif Moye; Richard S. Agnes; Peg Davis; Shou-Wu Ma; Josephine Lai; Frank Porreca; Vardanyan Ruben, and Victor J. Hruby “Development of m opioid receptor selective 4-anilinidopiperidine analogues” Understanding Biology Using Peptides, Proceeding of the 19th American Peptide Symposium, 2005, 591. James P. Cain; Alexander V. Mayorov; Minying Cai; Yeon Sun Lee; Jinfa Ying; and Victor J. Hruby “Design, synthesis, and evaluation of piperazine-based small molecule peptide mimetics targeting the melanocortin receptors” Understanding Biology Using Peptides, Proceeding of the 19th American Peptide Symposium, 2005, 550. Ravil R. Petrov; Ruben S. Vardanyan; Shou-Wu Ma; Peg Davis; Yeon Sun Lee; Minying Cai; Kathy A. Ciano; Henry I. Yamamura; and Victor J. Hruby “Synthesis and biological activities of chimeric bioactive peptides based on amino acids coupled to 4-anilino-N-phenethyl-piperidine” Understanding Biology Using Peptides, Proceeding of the 19th American Peptide Symposium, 2005, 535. Byung J. Min; Xuyuan Gu; Ravil R. Petrov; Yeon Sun Lee; and Victor J. Hruby “Design and synthesis of bicyclic internal b-turn mimetics and their applications toward biologically interesting ligands” Understanding Biology Using Peptides, Proceeding of the 19th American Peptide Symposium, 2005, 186. Ekaphol Wooden; Vinod Kulkarni;. Yeon Sun Lee; Richard S. Agnes; Christine Salibay; Peg Davis; Shou-Wu Ma; Josephine Lai; Frank Porreca; and Victor J. Hruby “Analogues of multifunctional ligands for opioid and CCK receptors” Understanding Biology Using Peptides, Proceeding of the 19th American Peptide Symposium, 2005, 361. Victor J. Hruby; Richard S. Agnes; Josef Vagner; Yeon Sun Lee; Heather Handl; Shou-Wu Ma; Peg Davis; Todd W. Vanderah; Henry I. Yamamura; Josephine Lai; Robert J. Gillies; Frank Porreca “Utilizing genomics and proteomics for peptide based drug design. Drug design for disease reconsidered” Peptides 2004: Bridges between Disciplines, Proceeding of the 4th International Peptide Symposium/28th European Peptide Symposium, 2005, 77. Yeon Sun Lee; Richard S. Agnes; Peg Davis; Shou-Wu Ma; Josephine Lai; Frank Porreca; Victor J. Hruby “Hydrazide linked bifunctional peptides for the treatment of pain” Peptide Revolution: Genomics, Proteomics & Therapeutics, Proceeding of the 3rd International Peptide Symposium/18th American Peptide Symposium, 2004, 682. Richard S. Agnes; Yeon Sun Lee; Peg Davis; Shou-Wu Ma; Todd W. Vanderah; Jinfa Ying; K Kover; Josephine Lai; Frank Porreca; Victor J. Hruby “New paradigm for drug design: overlapping pharmacophores of opioid and Cholecystokinin ligands in the design of new compounds for the treatment of neuropathic pain” Peptide Revolution: Genomics, Proteomics & Therapeutics, Proceeding of the 3rd International Peptide Symposium/18th American Peptide Symposium, 2004, 615. Vicror J. Hruby; Richard S. Agnes; Yeon Sun Lee; Peg Davis; Show-Wu Ma; Todd W. Vanderah; Joshephine Lai; Frank Porreca “Peptide and Peptide Mimetic Drug Design: New Paradigms, New Opportunities, New Ethical Concerns” 3rd Hellenic Forum on Bioactive Peptides, 2003, 29. Richard S. Agnes; Yeon Sun Lee; Peg Davis; Shou-Wu Ma; Josephine Lai; Frank Porreca; Victor J. Hruby “Design and Synthesis of Bifunctional Peptides: Antagonists at CCK-A/CCK-B receptors and agonist at Opioid Receptors”, Peptides: The Wave of the Future, Proceedings of the 17th American Peptide Symposium, 2001, 691. Victor J. Hruby; Richard S. Agnes; Yeon Sun Lee; Peg Davis; Shou-Wu Ma; Josephine Lai; Frank Porreca “Designing Peptide Drugs/Ligands for Pathological State. A New Paradigm for Design of Bioactive Peptide Hormones and Neurotransmitters”, Peptides: The Wave of the Future, Proceedings of the 17th American Peptide Symposium, 2001, 969. Yeon Sun Lee; Hyun Jin Lee; Doyoung Lee; Hack-Joo Kim “Nsc- and Fmoc-amino acids for Automated Solid Phase Peptide Synthesis: Comparative Study of the Stability in Various Conditions”, Peptides for the New Millennium, Proceedings of the 16th American Peptide Symposium, 2000, 53. Weonu Chweh; Young-Cheol Kim; Yeon Sun Lee; Hack-Joo Kim “Efficient Coupling Conditions of N-2-(4-Nitrophenylsulfonyl)ethyloxycarbonyl Amino Acids”, Peptides 1998, Proceedings of the 25th European Peptide Symposium, 1999, 104. Sun Ho Jung; Yeon Sun Lee; " Intramolecular Diels-Alder Reactions of Trienoates : Further Understanding of Stereoselectivities in the IMDA Reactions and Construction of [m,6,n]-Tricyclic Lactones" Annual Report of Basic Science Research Institute, Seongshin Women's University, Seoul, Korea, 1998.  Book Chapter Victor J. Hruby; Yeon Sun Lee; Minying Cai; Keith Olson; Michael Remesic “Peptide Therapeutics: Neuropeptides” in Peptide-based Drug Discovery: Challenges and New Therapeutics, 2017, The Royal Society of Chemistry, Ch. 13, pp.391. Victor J. Hruby; Frank Porreca; Henry I. Yamamura; Gordon Tollin; Ricahrd S. Agnes; Yeon Sun Lee; Minying Cai; Isabel Alves, Scott M. Cowell; Peg Davis; Zdzislaw Salamon; William Roeske; Todd W. Vanderah; Josephine Lai “New Paradigms and Tools in Drug Design for Pain and Addiction” in Drug Addiction: From Basic Research to Therapy,, 2008, Springer, Ch. 28, pp.477.