Nafees Ahmad
Professor, Immunobiology
Member of the Graduate Faculty
Professor, Applied BioSciences - GIDP
Professor, BIO5 Institute
Medical Research Building, 217A
Dr. Nafees Ahmad received his B. S.(Hons) and M. S. in Biochemistry & Microbiology from one of the prestigious central universities in India, The Aligarh Muslim University. He then joined another renowned research institute, The Central Drug Research Institute, Lucknow, India, from where he earned his Ph.D. in 1983. Dr. Ahmad did his Postdoctoral Fellowship at the National Institutes of Health (NIH), Bethesda, Maryland, USA from 1985-1990 in the Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases. His research primarily focused on the regulation of HIV-1 gene expression and replication, especially the role of HIV-1 regulatory and accessory proteins in HIV-1 replication and biology. In 1990, a group of scientists from the NIH, including Dr. Ahmad moved to J.N. Gamble Institute of Medical Research, Cincinnati, Ohio to start a new program on Molecular Virology, including his own independent research program on molecular mechanisms of HIV-1 mother-to-infant transmission. In 1994, Dr. Ahmad joined the University of Arizona College of Medicine's Department of Microbiology and Immunology (now Immunobiology). His research involves understanding the molecular mechanisms of differential HIV infection in infants and adults and vertical transmission and HIV infection in aging and older infected patients. In addition, he directs the Immunity and Infection block of the medical curriculum (M.D. program) of the College of Medicine. He is also the Director of Microbiology and Immunity Graduate Certificate Program and Director of Applied Biosciences Professional Masters Graduate Interdisciplinary Program - Medical Microbiology and Immunology Track. He teaches medical virology to M.D. students and molecular virology to M.S. and Ph.D. students. He mentors postdoctoral and medical fellows and graduate, medical and undergraduate students for research in his laboratory. His services include serving on various university, college, and departmental committees, grant review committees, editorial boards of scientific journals and other international, national and local agencies.
Research Interest
1. Viral, Immunological and Clinical Factors in HIV-1 Aging Patients: We are investigating the role of HIV infection in influencing the aging process of the immune system (immunosenescence) in older patients. We are elucidating the molecular properties of HIV in older infected patients whose viral load is suppressed by anti-retroviral drugs. These studies may provide new information to develop strategies for prevention and treatment of HIV infection in older infected patients, including improving the aging of the immune system in older population. 2. Mechanisms of HIV-1 replication in neonatal (immatur cord blood) and adult (mature) hosts T lymphocytes (naive and memory) and monocytes/macrophages, Cellular gene expression profile of cord and adult blood mononuclear cells, T-lymphocytes, macrophages by Microarray analysis, Use of siRNA/shRNA to interfere with cellular factor that influence HIV replication, Interaction of cellular factors from cord and adult cells with HIV LTR, HIV-1 infection and T-cell development, 3. Molecular mechanisms of pathogenesis of pediatric AIDS, Molecular and biological properties of HIV-1 in infected infants over time associated with pathogenesis and disease progression, Clinical parameters, including CD4 counts and viral load in HIV-1 infected infants during the course of infection and disease progression 4. Molecular mechanisms of HIV-1 mother-infant transmission, Genotypic and phenotypic characterization, cell tropism, viral determinants associated with vertical transmission. 5. Biological activity of anti-HIV agents, Effects of antivirals on HIV-1 replication in primary target cells. 6. Molecular biology of human immunodeficiency virus (HIV), Functional role of HIV-1 regulatory proteins in viral replication.
Offering Research Opportunities
Yes
Prerequisite Courses
None
Majors Considered
Most majors related to Biological and Biomedical Sciences, including Physiology and Medical Sciences, Microbiology, Molecular and Cellular Biology, Biochemistry, General Biology, Nutritional Sciences, Biomedical Engineering and others
Description of Opportunity
No description given